How a diet high in cholesterol may cause cardiovascular disorders.

I read this information from PRE-U TEXT STPM BILOLOGY, a diet rich in cholesterol may result in high blood cholesterol. CO, nicotine, hypertension and high blood cholesterol level cause damage to arterial endothelium. There is invasion by monocytes which develop into macrophages. Macrophages ingest cholesterol from LDLs. Smooth muscle cells also ingest cholesterol. The macrophages and smooth muscle cells transformed into foam cells. The foam cells together with accumulation of lipid( mainly cholesterol), Ca²⁺ and fibrous deposits from the athermatous plaque which is covered by a fibrous cap. It protrudes into the arterial lumen. The plaque causes narrowing of the arterial lumen, reduces oxygen supply to the heart and increases the risk of developing cardiovascular disorders example heart attack.