Asthma and Leukotrienes

I read this information from Organic Chemistry. Asthma is an obstructive lung disease that affects millions of Americans. Because it involves episodic constriction of small airways, bronchodilators such as albuterol and inhaled steroids
reduced inflammation )are used to treat symptoms by widening airways.Leukotrienes are molecules that contribute to the asthmatic response. Structure determination and chemical synthesis were difficult because leukotrienes are highly unstable and extremely potent, and are therefore present in tissues in exceedingly small amounts.